Splicers, also known as Aggressors, are the main enemies that Jack encounters over the course of the game. The remains of Rapture's human population, they are the result of a planned attack by Atlas (Fontaine) on New Year's Day, 1959 to end the civil war between him and Ryan. They apparently murdered the sane population. Many of them still wear Masquerade Ball masks, and Atlas asks, "I wonder why they wear masks? Maybe it's because they have a shred of humanity left, and they're ashamed of what they've become." Apparently due to the biological weapons attack, they have become biologically dependent on ADAM to survive. Wandering the corridors and the tunnels of Rapture, they search for ADAM, usually in the form of Little Sisters, which often puts them at odds with their Big Daddy protectors-something that Jack can easily exploit to help him survive. Splicers tend to wear very little armor, if any, but they have advanced physical strength and tend to be extremely aggressive in contrast to the calmer Big Daddys. They will sometimes work in groups, use plasmids and sometimes even play dead to get the advantage on the player. Splicers can be divided into several separate categories, based on the weapons that they prefer to use. * Thuggish splicers, who first appear in the Welcome to Rapture level. They attack by rushing the player with melee weapons, such as pipes and wrenches scavenged from the surrounding area. * Leadhead splicers, who use firearms. They first appear in the Welcome to Rapture level. * Nitro splicers, who first appear in the Medical Pavilion level and throw explosives such as mines, Molotov ------tails and makeshift bombs to attack Jack, something that can be exploited with the Telekinesis plasmid. * Spider splicers, who first appear in Neptune's Bounty, can crawl on the ceiling and throw hooked blades * Houdini splicers can teleport and attack the player with plasmids or other weapons. They first appear in the Arcadia level.
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