I'm not completely sure about this, but for fonts that you don't want to use or use not very often, you can put them in another folder. I read that you can open the file if you want to use it for the period of time it's open, as windows will recognize it as installed or something.
I dont know for sure, but I thought there was a folder in PS, called fonts and it would load all the fonts in there + the windows fonts. I'm not really sure as I do not have PS on my pc atm.
I know how that feels, I did that with brushes awhile back but I delete the extra ones, Because of that I only have like 6 or 7 downloaded fonts